Throughout history, epidemics have brought with it various factors that adversely affect societies. Plague, syphilis, malaria, flowers etc. that the communities have to struggle with. There are many epidemics. These have caused destroying. The living beings, including the lands where the Ottoman Empire was dominant, were also exposed to these epidemic diseases. In the late Ottoman period, it is known that they often fight against epidemic diseases. Especially in Antalya, which is an important port city in terms of its geographical position and functionality, outbreak of plague epidemic. Within the scope of the main objective of the study; In light of the Prime Ministry Ottoman Archival Documents and other research and investigation works, the plague cases and sanitary measures taken in Antalya between 1838-1920 have been mentioned. As a matter of fact, various measures have been taken to prevent the plague epidemic in this period. In the treatment of plague epidemic, methods such as serum, vaccine, quarantine have been applied. The measures taken to protect public health were evaluated within the framework of the health organization of the Ottoman State and the negative effects of the plague epidemic were examined.